Michael Andretti was born and raised in Bethlehem, Pennsylvania. Andretti is a retired auto racing driver and has been active as a manger and team owner since his retirement from racing.  

Statistically, Andretti is one of the most successful drivers in the history of American open-wheel car racing. Andretti won the 1991 CART PPG Indy Car World Series and amassed 42 race victories, the most in the CART era and fourth-most all time at the end of his career. Since his retirement from active racing, Andretti has owned and run Andretti Autosport, which has won mutliple IndyCar Series championships and five Indianapolis 500 races.

He is the son of Formula One World Champion and Indianapolis 500 winner Mario Andretti, and the father of IndyCar Series driver Marco Andretti. Michael was inducted in 2002 into National Italian American Sports Hall of Fame. He was inducted into the Motorsports Hall of Fame of America in 2008. At the beginning of 2018, he partnered with Ryan Walkinshaw's Walkinshaw Racing and Zak Brown's United Autosports to create Walkinshaw Andretti United which competes in the Australian Supercars Championship.