Stan Humphries is a former professional quarterback. He played high school football at Southwood High School and college football at Northeast Louisiana (now named the University of Louisiana at Monroe).

He played for the Washington Redskins (now the Washington Football Team) and San Diego Chargers (now the Los Angeles Chargers) of the NFL. He was selected by the Redskins in the sixth round of the 1988 NFL Draft. He made his first pro start in 1990 in Phoenix against the Cardinals, with regular starter Mark Rypien sidelined with an injury. Humphries went on to pass for 1,015 yards and three touchdowns in seven games in 1990. The following season, he won the Super Bowl ring with the Redskins as Rypien's backup. Humphries was traded to the San Diego Chargers before the start of the 1992 season following a preseason injury to starting Chargers QB John Friesz. The two teams ran the same offense, allowing Humphries to quickly make an impact. He passed for 3,356 yards, which ranked fifth in the league in 1992. He helped lead the Chargers, who were 4-12 in 1991 and stumbled out to an 0-4 start in 1992, to finish with an 11-5 record, winning the AFC West and ending the Chargers' decade-long playoff drought. 

As of 2021, the 1992 Chargers are the only team to go 11-5 after starting out 0-4. Also as of 2021, Humphries is a commentator for college football. He also hosts his namesake celebrity golf tournament, which has raised more than $1 million over the years for Rady Children's Hospital in San Diego.