Eli Manning is a former professional quarterback. While playing college football at Ole Miss, Manning won many awards: the Maxwell Award as the nation's best all-around player, the Johnny Unitas Golden Arm Award, the National Football Foundation and College Football Hall of Fame Scholar-Athlete Award, the Sporting News Radio Socrates Award, and the SEC Most Valuable Player Award.

Manning played in the NFL for 16 seasons, solely with the New York Giants. He was selected first overall in the 2004 NFL Draft by the San Diego Chargers, and was traded to the Giants. He is the youngest son of former NFL quarterback Archie Manning and brother of former quarterback Peyton Manning. Although Manning struggled with consistency throughout much of his career, he is recognized for twice leading the Giants to underdog Super Bowl victories against the New England Patriots' dynasty in Super Bowl XLII and Super Bowl XLVI. The former, which saw the wild card Giants defeat a Patriots team that was the first to win all 16 regular season games, is regarded as one of the greatest sports upsets of all time. Manning was named MVP in both games, making him one of five players to have multiple Super Bowl MVP's. As the Giants' starting quarterback from 2004 to 2019, Manning holds franchise records for most passing yards, touchdown passes and completed passes in a career (as of 2021).

Eli has served as a spokesman for Citizen Watch Co., Toyota of New Jersey, and Reebok.